通过诱导NLRP3乳化,LDHA会加剧心肌缺血-再输液损伤

Lixiang Fang1, Zhenfei Yu2, Xiaoling Qian2

  • 1The First People's Hospital of Chun'an County (Chun'an Branch of Zhejiang Provincial People's Hospital), Chun'an County, 1869 Huanhu North Road, Qiandao Lake Town, Zhejiang, 311700, China.

PubMed
概括

乳酸脱酶A (LDHA) 通过NLRP3乳化促进热致死,从而驱动反后的心脏损伤. 抑制LDHA或阻断NLRP3可以减少这种损伤,从而提供潜在的治疗点.

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