鉴定双胞胎死性肠球炎的危险因素:对10多年经验的病例对照匹配分析
Pengjian Zou1, Wenhai Fang1,2, Lili Wu3
1Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
BMC pediatrics
|November 16, 2024
概括
单胞胎双胞胎显示了死性肠球炎 (NEC) 的危险因素. 选择性胎儿生长限制 (sFGR) 是这些双胞胎对中NEC的独立风险因素.
科学领域:
- 新生儿护理 新生儿护理
- 产周医学 产周医学
- 双胞胎研究是关于双胞胎的研究.
背景情况:
- 死性肠球炎 (NEC) 是新生儿的关键性胃肠道疾病.
- 单双胞胎 (MCT) 提供了一个独特的模型来研究由于遗传同质性的非遗传风险因素.
研究的目的:
- 为了确定单双胞胎中NEC的风险因素.
- 探索围产期条件和生长差异在MCT对内NEC发育中的作用.
主要方法:
- 从2012年1月到2023年3月为85对MCT的医疗记录的回顾性审查.
- 具有和没有NEC的MCT对之间的围产,养和先前条件的比较.
- 后勤回归分析以确定NEC的独立风险因素.
主要成果:
- 选择性胎儿生长限制 (sFGR) 在MCT对与NEC (38.3%对6.7%) 中明显更普遍.
- 带异常,SGA婴儿,TTT和败血症在NEC组中也更常见.
- sFGR被确定为NEC的一个独立风险因素 (OR 6.81,P=0.001).
结论:
- 非遗传因素是MCT内的NEC病原体的主要驱动因素.
- 带异常,SGA,sFGR,TTT和败血症是NEC的重要危险因素.
- 选择性胎儿生长限制 (sFGR) 是单胞胎双胞胎中NEC的关键独立风险因素.
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