在人类核桃食干预中,肠道微生物群和乌罗的代谢之间的相关性
Huijia Liu1, John W Birk2, Anthony A Provatas3
1Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
BMC microbiology
|November 16, 2024
概括
核桃的消费显著改变了肠道微生物群的组成,并增加了尿液中的特定乌罗的代谢物. 尿素的这些变化与独特的肠道细菌及其推断的功能有关.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 乌罗利是肠道微生物中的基酸代谢产物,在核桃中发现.
- 尿酸氨酸生产的个体变化表明肠道微生物群的作用.
- 核桃的消费是一种饮食干预,用于研究这些宿主-微生物相互作用.
研究的目的:
- 为了研究肠道微生物群和尿路乌罗素水平之间的关系.
- 评估为期三周的核桃饮食干预对这些参数的影响.
- 为了识别特定的细菌种类和功能,与urolithin代谢相关.
主要方法:
- 从39个受试者的便和尿液样本的纵向采集.
- 16S rRNA基因测序用于便微生物组成分析.
- 在UHPLC/Q-TOF-MS/MS中,用于量化九种urolithin代谢物.
- 对推断的微生物功能含量进行PICRUSt分析.
主要成果:
- 核桃干预后便微生物组成 (α和β多样性) 的显著差异.
- 在核桃摄入后鉴定了13种显著丰富的细菌属.
- 26个属与7个乌罗的代谢产物相关,其中22个具有正相关性.
- 皮克鲁斯特的分析将推断出的KEGG正方体与4种乌罗的代谢产物联系起来.
结论:
- 核桃补充剂会改变尿道urolithin代谢物概况.
- 这些变化与肠道细菌种群的特定变化有关.
- 推断的微生物功能途径也与核桃摄入后的乌罗素代谢有关.
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