肝功能测试在预测COVID-19患者死亡率方面的有效性
Erdi Huseyin Erdem1, Bahar Aydinli1, Serkan Dogru1
1Mersin Sehir Education and Research Hospital, Anaesthesia and Reanimation Clinic, Turkey.
JPMA. The Journal of the Pakistan Medical Association
|November 16, 2024
概括
异常的肝功能测试,包括高胺转移酶和阿斯巴酸氨转移酶,低专蛋白,与危急的冠状病毒病-2019患者的死亡率增加有关.
科学领域:
- 关键护理医学 关键护理医学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 患有冠状病毒疾病-2019 (COVID-19) 危急病的患者经常表现出肝功能测试异常.
- 这些异常在COVID-19死亡率的预后意义仍然是积极调查的领域.
研究的目的:
- 为了调查肝功能测试 (LFT) 异常和COVID-19重症患者的死亡率之间的关联.
- 确定特定的LFT参数,预测该患者队列中的死亡率.
主要方法:
- 一项回顾性,单中心研究分析了2020年3月至2022年1月期间入院的940名危急COVID-19患者的数据.
- 根据正常或异常的肝酶和肝损伤,患者被分为几组.
- 记录了人口统计数据,并发症,ICU分数,血液样本,凝血和生物化学分析.
主要成果:
- 在940名患者中,56.8%的肝酶异常.
- 高的玛-氨基转移酶和酸氨基转移酶,以及低的专蛋白水平,被确定为死亡率的显著预测因子 (p<0.05).
结论:
- 特定的肝功能测试中的异常,包括高马-谷氨基转移酶和酸氨转移酶和降低的白蛋白,与重症COVID-19患者的较高死亡率有关.
- 这些LFT参数可以作为预测严重COVID-19病例死亡风险的有价值指标.
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