植物性支架和骨质生成:一个系统的审查
Hashmat Gul1, Kunza Naveed Asdaq1, Muhammad Kaleem1
1Department of Science of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
JPMA. The Journal of the Pakistan Medical Association
|November 16, 2024
概括
基于植物的支架显示出对骨再生和骨质生成的承诺. 然而,进一步的体内研究至关重要,以确定它们适用于骨组织工程应用的适用性.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 脱细胞化的植物组织为脚手架的发展提供了可持续和生物相容的来源.
- 在骨组织工程中,植物性材料是传统合成或动物衍生的支架的有希望的替代品.
研究的目的:
- 审查最近在植物性支架骨再生的进展.
- 增强对脱细胞化植物组织作为骨组织工程的支架的理解.
主要方法:
- 从2022年2月到6月进行了系统的文献审查.
- 搜索包括PubMed,Science Direct和谷歌学者,使用关键词与植物性脚手架和骨质生成相关.
- 在质量评估后,纳入了2013年至2022年间发表的十篇全文文章,重点是体外和体外研究.
主要成果:
- 六项研究 (60%) 是体外的,四项 (40%) 包括体外和体内组件.
- 在50%的研究中,去细胞化的植物组织被用作3D支架;在40%的研究中,复合支架被用作3D支架.
- 大多数研究 (70%) 呈现中等偏差风险.
结论:
- 植物性支架显示出促进骨质生成的潜力.
- 需要进行额外的体内研究来验证用于骨组织工程的植物性支架.
- 进一步的研究应该集中在优化基于植物的脚手架设计和评估它们在骨再生中的长期有效性.
相关概念视频
01:02What is the Skeletal System?
Overview
01:55Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:20Introduction to the Skeletal System
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...