过敏性鼻炎的鼻内药物的有效性和安全性:网络元分析
Bernardo Sousa-Pinto1,2, Rafael José Vieira1,2, Antonio Bognanni3,4
1MEDCIDS-Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.
Allergy
|November 16, 2024
概括
鼻内抗胰岛素 (INAH),鼻内皮质类固醇 (INCS) 和它们的组合 (INAH+INCS) 有效地治疗过敏性鼻炎 (AR). 组合疗法和INCS通常与单独INAH相比显示出更高的疗效,所有选择都显示出良好的安全性.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 鼻内抗胰岛素 (INAH),鼻内皮质类固醇 (INCS) 和它们的固定组合 (INAH+INCS) 是对过敏性鼻炎 (AR) 的主要治疗方法.
- 对它们的有效性和安全性的全面比较对于临床实践和指导方针的制定至关重要.
研究的目的:
- 进行系统性审查和网络元分析,比较INAH,INCS和INAH+INCS在AR患者的疗效和安全性.
- 确定对过敏性鼻炎最有效的鼻内治疗方法.
主要方法:
- 随机对照试验的系统综述和网络元分析,针对有季节性或多年性AR的成年人进行.
- 评估总鼻腔症状得分,总眼部症状得分,犀牛结膜炎生活质量问卷和不良事件.
- 使用GRADE-NMA评估证据确定性.
主要成果:
- 固定组合 (INAH+INCS) 和INCS是大多数结局中有效性排名最高的干预措施.
- 与其他治疗方法相比,阿泽拉斯-流动松和流动松酸盐显示出显著的改善.
- 在对季节性和多年性AR的大量比较中,发现了高或中等的证据确定性.
结论:
- 对AR的鼻内药物表现出临床上显著的疗效差异,组合疗法和INCS往往优越.
- 所有研究的鼻内治疗AR具有有利的安全性.
- 这个网络元分析为优化AR治疗指南和临床决策提供了关键证据.
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