超症会影响神经驱动和隔膜神经运动控制的时间
Obaid U Khurram1, Maximilian J Kantor-Gerber1, Carlos B Mantilla1,2
1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Journal of neurophysiology
|November 16, 2024
概括
超症会增加隔膜肌肉 (DIAm) 运动单元的招募和释放率. 然而,增加通风的主要机制是减少呼吸后的DIAm EMG活动,促进更高的呼吸速率.
科学领域:
- 身体生理学 身体生理学
- 神经科学是一个神经科学.
- 呼吸系统控制 呼吸系统控制
背景情况:
- 隔膜肌 (DIAm) 神经运动控制涉及招募,持续活动和退出,这对于保持通风至关重要.
- 超症对DIAm神经运动控制的确切影响仍然不完全理解.
研究的目的:
- 为了研究超症对清醒大鼠DIAm神经运动控制的影响.
- 阐明超症改变隔膜活动和通风的机制.
主要方法:
- 使用慢性细线电极记录了Sprague-Dawley大鼠在normocapnia和hypercapnia (7%CO2) 下的DIAm电动肌图 (EMG).
- 分析了DIAm EMG活动,以估计动力单元的招聘和退役时间和幅度 (RMS).
主要成果:
- 超头皮症将整体DIAm爆发的持续时间减少了40%左右,呼吸速率增加了50%左右.
- 突发持续时间的缩短主要是由于峰值抵消持续时间减少了57%,这表明压制后吸气活动.
- 超症增加了招聘和峰值EMG幅度 (分别为11%和23%),并消除了持续活动阶段的减少,增加了171%的退出招聘幅度.
结论:
- 超头皮症增加了DIAm运动单元的招募和放电率,与增加的呼吸驱动相一致.
- 在高头症期间增加通风的主要机制是缩短呼吸后 (降落) DIAm EMG活动阶段,促进更高的呼吸速率.
- 在高头症期间呼吸速率的增加主要是由DIAm EMG活动的下降坡道的修改驱动的.
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