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双触发器与人类胆管性腺激素触发器对胚胎细胞质量和累积活产的触发器

Zining He^1,2,3,4, Yalong Liu^1,2,3,4, Ning Huang^1,2,3,4

¹Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Haidian District, 49 Huayuan North Road, Beijing, People's Republic of China.

Journal of assisted reproduction and genetics

|November 16, 2024

概括

双触发器和人类胆性腺激素 (hCG) 触发器在不良和正常卵巢响应者的植入前遗传测试 (PGT) 周期中显示出类似的欧卵囊和活产率.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
遗传学是一个遗传学.

背景情况:

卵巢刺激方案旨在优化卵细胞产量和质量.
触发卵细胞成熟是体外受精 (IVF) 中的一个关键步骤.
植入前遗传测试 (PGT) 评估胚胎的染色体异常.

研究的目的:

为了比较双触发器与人类胆管性腺激素 (hCG) 触发器的有效性.
为了评估欧卵母细胞产量和累积活产率 (LBR).
为了评估接受PGT周期的卵巢反应不良和正常的卵巢反应者的结果.

主要方法:

对1040个试管婴儿-PGT和784个冷解胚胎移植 (FET) 周期的回顾性队列研究.
双触发器 (三烯酸+复合hCG) 与hCG触发器对卵细胞成熟的作用.
在FET之后对胚胎结果和累积LBR的分析.

主要成果:

在触发组之间,检索的卵细胞,MII卵细胞,胚胎囊或euploid胚胎囊没有显著差异.
双重和hCG触发组的可比累积活产率 (24.9%).双重和hCG触发组的可比累积活产率 (24.9%).
后勤回归显示触发方法和更高的LBR (OR = 1.040) 之间没有相关性.

结论:

双触发器与hCG触发器相比,不会改善PGT胚胎的结果.
在低/正常反应者中,没有观察到双重触发的增强累积妊娠结果.
目前的证据表明,在PGT周期中,双触发对hCG触发没有益处.

关键词:

累积活产率是指活产率的累积值.这是一个双触发器.欧普洛伊德胚胎囊是如何形成的人类胆性淋巴激素触发器

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