怀孕期间和产后前六个月的23个常见生物化学参数的参考间隔
Paul Kjetel Soldal Lillemoen1, Kristin Holstad1, Anne-Lise Bjørke-Monsen1,2,3
1Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Scandinavian journal of clinical and laboratory investigation
|November 16, 2024
概括
怀孕和产后显著改变生化标志物,需要不同的参考范围. 一些变化在分娩后持续数月,影响临床解释.
科学领域:
- 临床生物化学 临床生物化学
- 生殖医学 生殖医学
- 妇女健康 妇女健康
背景情况:
- 生物化学参数度在怀孕期间和产后波动.
- 确定的参考值可能不准确地反映这些生理状态.
- 具体的参考间隔对于准确的临床评估在孕妇和产后妇女至关重要.
研究的目的:
- 为怀孕和产后期间的常见生化参数建立参考间隔.
- 为了研究这些生化参数在整个妊娠和 puerperium 的动态.
- 为了比较孕妇/产后妇女的生物化学值与从未怀孕的对照者的生物化学值.
主要方法:
- 从139名健康的孕妇/产后妇女和59名对照妇女收集的血液样本.
- 血清分析了23个常见的生物化学参数.
- 根据IFCC/CLSI指南计算参考区间的非参数方法.
主要成果:
- 在怀孕期间和之后观察到生化参数的显著变化.
- 一些分析剂 (例如血清粉酶,高密度胆固醇) 与对照组没有显著差异.
- 血清酸酸酶,化物,-胺转移酶,和尿素的升高在分娩后的六个月内持续存在.
结论:
- 怀孕和哺乳期会引起深刻的生理变化,影响生化标志物.
- 具体的参考间隔对于准确解释孕妇和产后妇女的生物化学测试至关重要.
- 由于持续的变化,某些生化参数需要持续的产后监测.
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