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脊髓干细胞中的微细胞通过可溶性CD40调节神经前体细胞的增殖,以应对髓基蛋白

Nishanth Lakshman1,2, Filip Stojic2, Cindi M Morshead1,2,3,4

  • 1Department of Surgery, Division of Anatomy, University of Toronto, Toronto, ON M5S 1A8, Canada.

Stem cells (Dayton, Ohio)
|November 16, 2024
PubMed
概括

脊髓微细胞释放可溶性CD40 (sCD40) 作为对髓基蛋白 (MBP) 的反应,抑制神经干细胞 (NSC) 增殖. 这一发现为增强神经修复策略提供了一个目标.

关键词:
微质细胞中的微质细胞骨髓蛋白基本蛋白质是什么神经干细胞的神经干细胞脊髓是指脊髓的部分.干细胞的利基是干细胞.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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