训练有素的先天免疫力在系统性红斑狼中对核抗原的反应中
Cansu Yanginlar1, Nils Rother1, Tomas G J M Post1
1Department of Nephrology, Radboud Research Institute for Medical Innovation, Radboud university medical center, Nijmegen, the Netherlands.
Journal of autoimmunity
|November 16, 2024
概括
核自身抗原如微粒和NETs可以诱导系统性红斑狼 (SLE) 患者的训练免疫力. 这种先天的免疫记忆有助于在SLE中观察到的免疫失调.
科学领域:
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
- 天生免疫记忆天生的免疫记忆
背景情况:
- 系统性红斑狼 (SLE) 是一种针对核抗原的自身免疫性疾病.
- 训练免疫是一种先天的免疫记忆,增强炎症反应.
- 核自身抗原在诱导SLE训练免疫的作用尚不清楚.
研究的目的:
- 调查核自身抗原是否可以诱导SLE患者的训练免疫力.
- 探索与SLE单细胞训练免疫相关的功能,转录和表观遗传变化.
主要方法:
- 从SLE患者中分离出来的单细胞被核抗原,微粒 (MP),中性粒细胞外细胞陷 (NET) 或SLE血刺激.
- 细胞经历了五天的休息期,然后再用托尔类受体 (TLR) 激动剂进行再刺激.
- 通过ELISA测量细胞因子的产生;使用流细胞计,RNA测序和ChIP测序来评估功能,转录和表观遗传变化.
主要成果:
- 用MPs,NETs和SLE进行体外刺激,可在单细胞中诱导受训免疫力.
- 来自SLE患者的循环单细胞在TLR连接体刺激后表现出增强的促炎性细胞因子产生,表明受过训练的免疫力.
- 观察到表观遗传变化,特别是基因组3 lysine 4三甲基化,以及新陈代谢和炎症基因的表达增加.
结论:
- 核自身抗原可以在SLE中诱导训练免疫.
- 训练有素的免疫力在SLE特征的免疫失调中起作用.
- 这些发现突出了一个新的机制,有助于SLE的发病.
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