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Updated: Jun 7, 2025

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

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基于单分子FRET的方法用于针对蛋白质的药物发现

Yuyoung Kim1, Surim Kim1, Kang Heo2

  • 1Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul 06591, Republic of Korea.

Molecules and cells
|November 16, 2024
PubMed
概括

一种新的单分子光方法快速选针对II型多酶的候选药物. 这种技术揭示了药物机制,有助于发现新的抗癌和抗菌化疗.

关键词:
双二氧化物和多二氧化物.药物查是指对药物进行查.这种类型的Etoposide.单分子光共振传输能量转移.第二种类型的拓聚酶.

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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