可以改善氧化脂介导的丸功能障碍和在成年Wistar大鼠暴露于Bisphenol A后的 epididymal精子异常

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Meenu Maniradhan¹, Narmadhaa Sivagurunathan¹, Ajay Krishnan Unnikrishnan²

¹Molecular Pharmacology and Toxicology Laboratory, Department of Biotechnology, School of Integrative Biology, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu 610005, India.

Reproductive toxicology (Elmsford, N.Y.)

|November 16, 2024

概括

(Se) 保护雄性大鼠免受双A (BPA) 引起的生殖损伤. 通过减少氧化应激和恢复抗氧化酶活性,Se补充改善了丸功能和精子参数.

科学领域:

生殖毒理学生殖毒理学
内分泌学在内分泌学.
环境健康环境健康

背景情况:

双A (BPA) 是一种内分泌干扰化学物质,与男性生殖健康问题有关.
暴露于BPA可能会破坏精子生成,丸功能和荷尔蒙信号传递.
BPA对丸有毒性的确切机制尚未完全理解.

研究的目的:

为了研究BPA诱导的丸异常的机制.
评估 (Se) 对BPA毒性的保护作用.

主要方法:

成年雄性Wistar大鼠被分为四组.
BPA (50毫克/公斤) 服用了30天,与或没有Se (2.5毫克/公斤) 补充剂开始一周前.
评估丸结构,精子参数,氧化应激标志物和关键酶活动.

主要成果:

暴露于BPA会损害丸结构,减少精子数量,增加氧化应激标志物 (氧化脂,脂类过氧化物,基).
BPA降低了抗氧化酶活动 (超氧化脱酶,酸酶,谷氨酸过氧化酶,谷氨酸减少酶) 和类固醇酶 (3β-和17β-氧化类固醇脱酶).
同时服用Se减轻了BPA的副作用,减少了氧化应激,改善了丸和精子的参数.

结论:

通过氧化应激和破坏类固醇生成,BPA会诱导丸功能障碍.
(Se) 有效地保护大鼠免受BPA诱导的雄性生殖毒性.
它在缓解内分泌干扰剂诱导的丸损伤方面发挥着至关重要的作用.

关键词:

双 A 是一种双.内分泌干扰物干扰内分泌干扰物氧化应激是一种氧化应激.是一种.精子精子精子类固醇的产生.测试 (Testis) 是一个测试.

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