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通过腹部计算机断层扫描评估的低骨肌肉密度预测了患有慢性脏疾病的儿童的结果

Meiqiu Wang¹, Zijian Chen², Tingting Yu³

¹Department of Pediatrics, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

|November 16, 2024

概括

患有慢性病 (CKD) 的儿童显示骨肌肉密度 (SMD) 降低. 儿科CKD患者的低SMD与较高的功能衰竭风险有关,这突显了其对预后的重要性.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
儿科儿科儿科
身体组成分析身体成分分析

背景情况:

骨肌肉损失和脂肪分布变化预测成人慢性病 (CKD) 的结果不好.
身体构成对儿科CKD预后的影响尚不清楚.

研究的目的:

研究身体组成,特别是骨肌肉和脂肪组织,与患有CKD的儿童的临床结果之间的关系.
为了比较患有CKD的儿童和健康对照的身体组成.

主要方法:

追溯单中心研究,比较第三腰椎 (L3) 的身体组成,使用腹部计算机断层扫描在患有CKD的儿童和健康对照中.
主要结局定义为进展至血液透析,腹腔透析,移植或死亡.
使用后勤回归,多变量考克斯回归和卡普兰-梅尔生存分析来评估关联和风险因素.

主要成果:

与健康儿童相比,患有CKD的儿童表现出较低的骨肌面积,骨肌密度 (SMD) 和骨肌指数.
在患有CKD的儿童中,内脏脂肪面积和内脏脂肪指数显著更高.
低SMD与低甘油三水平独立相关,并且是较差无事件生存率的显著预测因素.

结论:

儿科CKD与显著的骨肌损失和骨肌密度 (SMD) 降低有关.
低骨肌密度 (SMD) 是慢性病 (CKD) 儿童预后不佳的关键指标.

关键词:

这就是为什么CTCTCTCTCTCT 孩子们的孩子们的孩子们的孩子们.慢性脏疾病慢性脏疾病骨髓骨质炎 (myosteatosis) 是一种疾病.骨肌肉的密度骨肌肉的密度

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