中国草药配方对格雷夫斯甲状腺功能障碍的临床疗效:一个多中心,随机,双盲,安慰剂控制的临床试验
Di Gan1, Tian-Shu Gao2, Li Ma3
1The First Clinical College of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, PR China.
Journal of ethnopharmacology
|November 16, 2024
概括
这项研究表明,Pingkang颗粒与甲基马 (MMI) 结合时,有效降低甲状腺激素水平,改善患者在格雷夫斯病 (GD) 中报告的结果. 草药配方也显示出作为单一治疗的好处,没有报告严重的不良事件.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 格雷夫斯病 (GD) 是甲状腺功能障碍的一种形式.
- 康颗粒,一种经过修改的Haizao Yuhu,是一种传统的中国草药配方,用于GD.
- 在GD管理中,Pingkang颗粒的高质量证据有限.
研究的目的:
- 评估Pingkang颗粒在治疗格雷夫斯甲状腺功能障碍症中的有效性和安全性.
- 通过随机对照试验提供高质量的临床证据.
主要方法:
- 一个多中心,随机,双盲,安慰剂对照试验,涉及186名患者.
- 患者接受了甲基马 (MMI) 与平康颗粒或安慰剂,或平康颗粒单一治疗12周.
- 主要结局包括血清FT3和FT4水平;次要结局包括TRAb,甲状腺体积,STA-PSV和ThyPRO39分数.
主要成果:
- 所有治疗方案都显著降低了血清FT3和FT4水平.
- 结合MMI和Pingkang颗粒,显著降低了血清TRAb水平.
- 康颗粒单疗法改善了甲状腺功能障碍相关的症状,包括眼睛,疲劳,认知,抑郁和易感性.
结论:
- 康颗粒,特别是与MMI结合使用时,可以有效地减少Graves甲状腺功能障碍的关键标志物.
- 治疗表明患者报告的结果和甲状腺功能显著改善.
- 平安康颗粒显示出与安慰剂和MMI相似的安全性.
相关概念视频
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Drugs for Treatment of Constipation-Predominant IBS
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...


