丸激素治疗对低阴腺男性良性前列腺增生症的影响
Kiarad Fendereski1, Joshua John Horns1, Hojat Dehghanbanadaki1
1Division of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT.
Urology
|November 16, 2024
概括
丸激素治疗 (TT) 增加了长期良性前列腺增生症 (BPH) 诊断的风险. 然而,TT并没有显著改变这些患者需要前列腺干预的需要.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医疗信息学 医疗信息学
背景情况:
- 双胞胎缺激素是一种不足丸激素生产的情况.
- 疗法 (TT) 是一种常见的治疗低性恋症的方法.
- TT对前列腺健康的长期影响,特别是良性前列腺增生症 (BPH),需要进一步研究.
研究的目的:
- 为了评估TT对BPH发病率在男性下腺的影响.
- 在这个队列中评估TT和前列腺干预措施之间的关联.
主要方法:
- 从2011-2020年IBM MarketScan数据库中确定了大量的阴茎下男性 (年龄大于18岁).
- 考克斯的比例危险模型分析了TT对BPH诊断和干预措施的影响,并对共变量进行了调整.
- TT被视为时间变化的协变量.
主要成果:
- 在882,570名低腺男性中,17.8%被诊断患有BPH.
- 在TT的前2.5年内,没有观察到BPH诊断的显著差异.
- 在2.5年后,TT与BPH诊断风险增加32%有关 (HR: 1.32).
- 在患有BPH的男性中,TT并没有显著改变前列腺干预率 (HR:0.95).
结论:
- 长期的丸激素治疗与低腺男性BPH诊断的风险增加有关.
- 丸激素治疗似乎不会影响在被诊断患有BPH的阴腺男性中进行前列腺干预的要求.
相关概念视频
Testosterone: Functions and Regulation
560
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
560
Disorders of the Male Reproductive System
337
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
337
Infertility in Males
250
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
250
Signs of Puberty
263
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
263
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Menopause
140
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
140


