大脑微型血流与结构网络破坏和白质超强度的认知障碍有关
Jiabin Yin1, Xia Zhou1, Yali Chen1
1Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Neuroscience
|November 16, 2024
概括
大脑微血细胞 (CMB) 或深层/脑下CMB的高数量会破坏白质网络,影响白质过强度患者的注意力和处理速度等认知功能.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 网络科学 网络科学
背景情况:
- 白质超强度 (WMHs) 在衰老和神经疾病中很常见.
- 大脑微出血 (CMB) 是小的出血,可以影响大脑结构和功能.
- 在WMH患者中,CMBs,白质结构网络和认知障碍之间的关系需要进一步阐明.
研究的目的:
- 研究CMBs与白质结构网络完整性在WMH患者之间的关联.
- 探索这些网络变化与认知缺陷之间的相关性.
主要方法:
- 158名WMH患者接受了3.0T MRI和神经心理测试.
- 参与者根据CMB数量 (非CMB,<5,≥5) 和分布 (严格的叶片与深层/下垂体) 进行分组.
- 扩散张力成像 (DTI) 用于构建白质结构网络并分析拓参数.
主要成果:
- 患有≥5个CMB或深层/下CMB的患者在白质网络中显示出全球效率降低和特征路径长度增加.
- 左中椎 (MOG.L) 和左椎 (CUN.L) 的特定节点网络改变与认知得分 (SCWT-A,MMSE) 相相关.
- 在患有<5个CMB或严格的叶叶CMB的患者中,没有发现显著的认知相关性.
结论:
- 高负荷 (≥5) 或CMB的特定位置 (深层/下层) 与WMH患者的白质结构网络中断有关.
- 这些干扰,特别是影响叶视觉网络,导致信息处理速度和注意力受损.
- 这些发现突显了CMB负担和位置在了解WMH患者认知衰退方面的临床相关性.
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