血calprotectin作为性结肠炎炎炎症活动的生物标志物
Maria José Temido1, Margarida Peixinho2, Rosário Cunha2
1Gastroenterology Department, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal.
血calprotectin (PC) 显示出有限的能力,以区分性结肠炎 (UC) 患者在缓解和那些有活跃疾病. 便calprotectin (FCP) 仍然是评估UC炎症活性的主要生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 生物标志物发现发现
背景情况:
- 性结肠炎 (UC) 需要更好的炎症负担评估工具.
- 目前的生物标志物,如便calprotectin (FCP) 和C反应蛋白 (CRP) 有局限性.
- 血calprotectin (PC) 是潜在的生物标志物用于炎症性疾病,包括UC.
研究的目的:
- 为了评估血calprotectin (PC) 和UC患者的炎症活性之间的相关性.
- 为了确定PC是否能够有效地区分活跃UC和缓解状态.
主要方法:
- 前性单中心队列研究,包括98名接受内镜检查的UC患者.
- 收集的人口,临床,内镜和组织学数据.
- 使用两种免疫检测方法 (Gentian和INOVA) 与CRP和FCP一起评估PC.
主要成果:
- PC,CRP和FCP分为中度/严重 (MES 2/3) 和轻度/无 (MES 0/1) 的内活动.
- 便calprotectin (FCP) 是唯一的生物标志物来识别内镜 (MES=1) 和组织学 (GS<2) 缓解.
- 血calprotectin (PC) 与CRP的相关性很高,但在区分UC缓解方面价值较低.
结论:
- 血calprotectin (PC) 不是区分UC缓解和活跃疾病的可靠标志物.
- 便calprotectin (FCP) 仍然是评估UC炎症活动和缓解的重要生物标志物.
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