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利索桑G (发酵小麦) 在减肥手术后反应性低血糖症的有效性
Diego Moriconi1, Laura Pucci2, Vincenzo Longo2
1Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Obesity research & clinical practice
|November 16, 2024
概括
利索桑G通过减弱肠道荷尔蒙反应,显著降低了腹后低血糖症 (PBH) 的发作. 这种发酵小麦补充剂为管理PBH并发症提供了有希望的食补充剂.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 腹后低血糖症 (PBH) 影响高达30%的Roux-en-Y胃绕道 (RYGB) 后的患者.
- 目前的PBH管理主要依赖于饮食调整以减轻发作频率.
- 了解肠-胰腺轴对于开发有效的PBH治疗至关重要.
研究的目的:
- 评估基于发酵小麦的补充剂Lisosan G (LG) 在减少PBH发作中的有效性.
- 在PBH患者中研究LG在肠-胰腺轴上的作用机制.
- 评估LG对葡萄糖水平,GLP-1和胰岛素分泌的影响.
主要方法:
- 这是一项前性研究,涉及20名RYGB后的PBH受试者.
- 持续血糖监测 (CGM) 和口服葡萄糖耐受性测试 (OGTT) 在补充LG之前和之后进行.
- 测量包括葡萄糖最低值,GLP-1 AUC和胰岛素AUC.
主要成果:
- 补充LG显著减少了PBH发作的时间 (75到16分钟).
- 在OGTT期间观察到葡萄糖最低值的显著增加 (44至56毫克/分升).
- LG导致GLP-1总AUC和总胰岛素AUC降低,这表明荷尔蒙反应减弱.
结论:
- 利索桑G有效地减少了腹后低血糖症的频率和持续时间.
- LG可能会减弱GLP-1度,降低胰岛素分泌的第二阶段.
- 作为一种新的饮食辅助疗法,LG显示出对管理PBH的承诺.
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