在接受癌症治疗的患者中,随着时间的推移,根据大麻使用状况的症状轨迹
Taylor Niznik1, Laili K Boozary1, Meng Chen1,2
1TSET Health Promotion Research Center, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA.
Scientific reports
|November 16, 2024
概括
癌症患者使用大麻与随着时间的推移增加症状严重程度和身体功能恶化有关,这挑战了对其在症状管理方面的益处的看法.
科学领域:
- 在瘤学瘤学.
- 症状管理 症状管理
- 大麻素研究 研究 大麻素研究
背景情况:
- 患有癌症的成年人经常探索大麻以缓解症状,但临床证据仍然没有确定性.
- 了解大麻对癌症相关症状的影响对于患者护理至关重要.
研究的目的:
- 研究大麻使用模式与成人癌症患者癌症相关症状轨迹之间的关联.
- 分析不同程度的大麻使用 (不使用,偶尔,持续) 如何影响癌症治疗期间的症状严重程度和生活质量.
主要方法:
- 一项纵向研究涉及218名在斯蒂芬森癌症中心接受治疗的成人癌症患者.
- 数据收集包括自我报告的大麻使用,身体和心理困扰 (罗德堡症状清单),呼吸系统症状 (美国胸腔协会问卷) 和生活质量 (PROMIS-29) 在基线和2,4,6个月.
- 使用纵向层次线性建模来评估大麻使用状态和症状轨迹之间的关系.
主要成果:
- 三分之一的参与者报告在研究期间使用大麻.
- 与非使用者相比,偶尔和持续使用大麻的人均报告了较高的整体症状严重程度.
- 在6个月的研究期间,持续使用大麻与身体功能下降有关.
结论:
- 癌症患者使用大麻与增加症状负担和随着时间的推移对身体功能产生潜在的负面影响有关.
- 这些发现表明,大麻对癌症患者症状管理的感知益处可能会被症状严重程度增加和功能衰退所抵消.
相关概念视频
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
202
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
202
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:17Classification of Illness
7.4K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.4K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K