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戈尔吉陷的自身炎症患者CDC42表现出细胞内交通缺陷,导致STING过度激活和ER压力

Alberto Iannuzzo1, Selket Delafontaine2,3, Rana El Masri1,4

  • 1Université Paris Cité, CNRS, Inserm, Institut Cochin, F-75014, Paris, France.

Nature communications
|November 16, 2024
PubMed
概括

疾病预防控制中心42的突变通过将蛋白质困在戈尔吉器官中引起自身炎症性疾病. 这导致STING通路过度激活和I型干扰素反应,解释了患者的严重症状.

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