相关实验视频

Updated: Jun 7, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

GPRC5A促进了食道状细胞癌的肺部殖民

Hongyu Zhou¹, Licheng Tan¹, Baifeng Zhang^1,2,3

¹Department of Clinical Oncology, Centre for Cancer Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Nature communications

|November 16, 2024

概括

肺部的早期食道癌细胞表现出类似于热囊细胞的表型,有助于转移. 过度表达GPRC5A促进了这一点,为食道状细胞癌 (ESCC) 肺转移提供了一个新的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症转移研究癌症转移研究

背景情况:

癌细胞可以在早期扩散,在形成可检测的转移之前.
早期扩散癌细胞 (DCC) 播种和成长为瘤的机制尚不清楚.

研究的目的:

研究食道状细胞癌 (ESCC) 中早期扩散癌细胞 (DCC) 的表型和机制.
确定ESCC肺转移的潜在治疗点.

主要方法:

从ESCC患者的肺DCC单细胞RNA测序.
分析GPRC5A表达及其在转移中的作用.
调查了GPRC5A/WWP1/LATS1/YAP1信号通路. 这是一个很好的例子.
对YAP1轴的治疗向.

主要成果:

肺部DCC的ESCC表现出一种类似于热囊细胞的"瘤植入"表型.
过度表达GPRC5A增强了DCC的植入,持久性和肺转移的形成.
升高的GPRC5A与较差的患者结果相关.
GPRC5A与WWP1相互作用,降低LATS1,激活YAP1的信号传输.
针对YAP1轴 (CA3,TED-347) 减少了植入和转移.

结论:

在ESCC肺转移中,GPRC5A/WWP1/LATS1/YAP1通路至关重要.
GPRC5A是ESCC的潜在生物标志物和治疗目标.
向YAP1在预防或治疗ESCC肺转移方面表现有前途.

更多相关视频

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

相关概念视频

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...