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Updated: Jun 7, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

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抑制EZH2可使突肉瘤中视网膜酸驱动的衰老变得敏感

Muhammad Mushtaq1,2, Judit Liaño-Pons3, Jiansheng Wang4

  • 1Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum, Karolinska Institutet, SE-171 65, Stockholm, Sweden. muhammad.mushtaq1@buitms.edu.pk.

Cell death & disease
|November 16, 2024
PubMed
概括

突肉瘤 (SS) 涉及SS18-SSXcoprotein驱动偏向表达抗原在黑色素瘤 (PRAME) 的表达. 这会破坏视网膜酸 (RA) 信号传输,但是用EZH2抑制剂和ATRA准这个复合体可以恢复信号传输,抑制SS生长,并诱导衰老.

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