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Updated: Jun 7, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners
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产生和验证可再生的affimer蛋白结合试剂,针对SH2域

Sophie J Heseltine1, Gregory J Billenness1, Heather L Martin1

  • 1School of Molecular and Cellular Biology, University of Leeds, Leeds, UK.

Scientific reports
|November 16, 2024
PubMed
概括

研究人员开发了新的affimer试剂,以准特定的sh2域,在癌症等疾病中至关重要. 这些工具使新的查方法成为可能,并显示出开发特定领域抑制剂的潜力.

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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