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膀癌中的与氧化还原相关的lncRNA特征

Fuguang Zhao^1,2, Hui Xie³, Yawei Guan^1,2

¹Department of Urology, The Third Medical Center, Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100039, P.R. China.

Scientific reports

|November 16, 2024

概括

这项研究确定了八种与氧化还原相关的长非编码RNA (lncRNAs),它们形成了预测膀癌 (BCa) 预后的特征. 这个签名准确地预测了患者的生存率和潜在的治疗反应.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

转毒状态对癌症的发展和进展至关重要.
长非编码RNAs (lncRNAs) 可以调节与癌症相关的氧化还原调节.
对于膀癌 (BCa) 的预后,需要一种特定的与氧化还原相关的lncRNA签名.

研究的目的:

建立一种新的与氧化还原相关的lncRNA签名,以改善BCa患者的预后预测.
确定与BCa中的氧化还原状态和生存相关的关键lncRNAs.
评估签名的预测准确性和临床相关性.

主要方法:

从癌症基因组图谱 (TCGA) 下载了转录组和临床数据.
采用单变Cox,LASSO和多变Cox回归分析来确定预后 lncRNAs.
使用8个选择的与氧化还原相关的lncRNA构建了一个风险模型,并进行了生存分析和基因组丰富分析 (GSEA).

主要成果:

已经确定了八个与氧化还原相关的lncRNAs (AC018653.3,AC090229.1,AL357033.4,AL662844.4,AP003352.1,LINC00649,LINC01138,MAFG-DT) 的签名.
高风险组的整体存活率明显低于低风险组 (p < 0.001).
该签名显示出比传统的临床病理特征更高的预测准确性,并在高风险组中确定了丰富的MAPK和Wnt信号通路.

结论:

开发的八个与氧化还原相关的lncRNA签名准确且独立地预测BCa患者的预后.
签名可以指导个性化治疗策略,因为高风险患者对特定化疗的敏感性增加.
作为MAFG-DT的标,IGF2BP2的过度表达与BCa中较差的OS相关.

关键词:

膀癌是一种癌症.化疗化疗是一种化学疗法.氧化还原剂的使用方法在 lncRNA 中,

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