在极度早产婴儿中尿路I-FABP的纵向分析,这些婴儿患有死角性肠球炎
Jennifer B Fundora1, Darla R Shores2, Allen D Everett2
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jfundor1@jhmi.edu.
Pediatric research
|November 16, 2024
概括
尿肠脂肪酸结合蛋白 (I-FABP) 在早产婴儿的结核性肠球炎 (NEC) 诊断时升高,但在NEC后降低. 然而,I-FABP水平并不能预测与NEC相关的胃肠道或神经发育结果.
科学领域:
- 新生儿研究新生儿研究
- 胃肠病学 胃肠病学
- 发现生物标志物的发现.
背景情况:
- 肠道脂肪酸结合蛋白 (I-FABP) 是一种肠道上皮蛋白.
- 在患有死角性肠球炎 (NEC) 的婴儿中,可以检测到I-FABP.
- 在NEC中I-FABP的纵向行为和预测值是未知的.
研究的目的:
- 为了比较患有和没有NEC的婴儿的尿液I-FABP水平.
- 研究I-FABP水平与NEC婴儿短期和神经发育结果的关联.
主要方法:
- 预预期红蛋白神经保护试验的二次分析.
- 在匹配的婴儿中使用ELISA进行序列尿液I-FABP测量 (n=70).
- 非参数分析以确定与结果的关联.
主要成果:
- 与对照组相比,患有NEC的婴儿在诊断时显示出较高的I-FABP (11对2.6ng/ml) 和NEC后较低的水平 (1对5ng/ml).
- NEC诊断与胆固醇,死亡,严重的神经发育障碍,脑和较低的运动分数有关.
- 诊断I-FABP水平与胃肠道或神经发育结果无关.
结论:
- 尿液I-FABP在NEC诊断时升高,在极度早产婴儿中在NEC后降低.
- 在NEC诊断时I-FABP水平不能预测消化道或神经发育不良结果.
- 尿路I-FABP可能有助于NEC诊断,但不能预测结果.
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