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牛皮的生物治疗对牛皮关节炎发展的影响:基于人口的队列研究

Yongtai Cho¹, Suneun Park², Kyungyeon Jung³

¹School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, South Korea.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

|November 17, 2024

概括

与瘤坏死因子 (TNF) 抑制剂相比,介质素 (IL) 抑制剂,特别是IL-23抑制剂,显著降低了牛皮患者患牛皮性关节炎 (PsA) 的风险.

科学领域:

皮肤病学皮肤病学
类风湿病学类风湿病学
免疫学免疫学免疫学

背景情况:

牛皮是一种慢性炎症状况,具有进展到牛皮关节炎 (PsA) 的显著风险.
存在有限的证据来比较不同生物疗法的有效性,以防止PsA的发展.
瘤亡因子 (TNF) 抑制剂是一种常见的治疗方法,但较新的干白素 (IL) 抑制剂提供了替代的作用机制.

研究的目的:

为了比较使用不同类别的生物药物治疗牛皮病患者患牛皮性关节炎 (PsA) 的风险.
具体来说,要评估IL-23抑制剂,IL-17抑制剂和IL-12/23抑制剂与TNF抑制剂在预防PsA发作的相关性.

主要方法:

一项基于人口的队列研究,利用韩国2007-2023年全国索赔数据.
没有先前存在的PsA或其他炎症性关节炎的新诊断的牛皮患者被根据他们最初的生物治疗 (IL或TNF抑制剂) 分类.
用多项重叠权重和Cox比例危险模型来计算发生的PsA的危险比率 (HR) 和95%置信区间 (CI).

主要成果:

该研究包括9499名牛皮患者,41.2%接受IL-23抑制剂,22.4%IL-17抑制剂,28.8%IL-12/23抑制剂和7.7%TNF抑制剂.
在23,275人年以上的患者中,3.0%的患者出现了PsA.
任何IL抑制剂的使用都与显着降低PsA风险相关 (HR 0.40;95% CI 0.25-0.62),IL-23抑制剂显示最大的风险降低 (HR 0.22;95% CI 0.13-0.37).

结论:

在患有牛皮的患者中,与TNF抑制剂相比,干白素 (IL) 抑制剂,特别是IL-23抑制剂与患牛皮关节炎 (PsA) 的风险降低有关.
这些发现表明IL向疗法在预防从牛皮到PsA的进展方面具有潜在的益处.
进一步的研究可能会阐明最佳的生物策略来管理牛皮和预防关节的参与.

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