对双截断和间隔审查的竞争性风险数据的累积发病率函数的非参数估计
1Department of Statistics, Tunghai University, Taichung, 40704, Taiwan. psshen@thu.edu.tw.
Lifetime data analysis
|November 17, 2024
概括
这项研究引入了一种新的方法来分析来自疾病登记册的双重截断和间隔审查的竞争风险 (DTIC-C) 数据. 拟议的非参数估计器准确地估计疾病登记数据的累积发病率函数 (CIF).
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 生存分析的分析.
背景情况:
- 间隔采样对于疾病登记册数据是常见的.
- 这种采样可以导致双重截断和间隔审查 (DTIC) 数据.
- 竞争性风险分析对于了解疾病进展至关重要.
研究的目的:
- 为累积发病率函数 (CIF) 开发非参数估计器,使用双截断和间隔审查的竞争性风险 (DTIC-C) 数据.
- 为应对疾病登记处间隔采样所带来的挑战.
- 为分析复杂的生存数据提供一个强大的方法.
主要方法:
- 使用非参数最大概率估计器 (NPMLE) 方法.
- 对DTIC-C数据进行了调整的沈氏方法 (Stat Methods Med Res 31:1157-1170, 2022b).
- 开发并建立了新的非参数CIF估计器的一致性.
主要成果:
- 用DTIC-C数据成功获得了CIF的非参数估计器.
- 确定了拟议估计者的一致性.
- 模拟研究表明,在有限的样本大小下表现良好.
结论:
- 建议的非参数估计器对间隔采样DTIC-C数据有效.
- 这种方法为疾病登记册分析提供了有价值的工具.
- 这些估计结果对现实世界流行病学研究具有前景.
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