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通过含有阿片类药物和阿片类药物的血液从外到头发的污染

Alexandre Czech¹, Julien Scala-Bertola², Elise Pape²

¹Université de Lorraine, CHRU Nancy, Department of Legal Medicine, Nancy F-54000, France.

Forensic science international

|November 17, 2024

概括

头发通过血液的外部污染可以导致药物测试中的错误阳性. 这项研究表明,阿片类药物和阿片类药物从受污染的血液中迅速融入头发,代谢物比率可能表明外部暴露.

科学领域:

法医毒理学法医毒理学
分析化学分析化学
药理学药理学是一个学科.

背景情况:

头发药物分析对于法医调查至关重要.
尸体解读需要考虑外部污染,特别是来自血液的污染,以防止假阳性.
片和阿片类药物是法医毒理学中经常测试的药物.

研究的目的:

为了评估各种阿片类药物和阿片类药物的纳入血液中的头发.
为了确定血液的外部污染是否导致头发度超过了法医界限.
评估代谢物与原始药物比率作为外部血液污染指标的有用性.

主要方法:

头发丝被故意污染,浸泡在血液中,其中含有已知度的吗啡,6 - 单乙吗啡,可代因,二可代因,特拉马多尔,氧,甲,EDDP,布普伦诺芬和诺布普伦诺芬.
污染的头发样本被存储在室温或4°C,持续时间不同 (6小时至14天).
头发样本在分析前经过广泛的洗以去除外部污染物.

主要成果:

所有测试的阿片类药物和阿片类药物都在几个小时内被纳入头发,无论储存温度 (RT或4°C).
在14天的研究期间,公司注册水平保持相对稳定.
头发度达到头发检测协会 (SoHT) 的切断水平,这表明可能会因外部污染导致错误阳性.
特定的代谢物与原始药物比率 (诺布诺芬/布诺芬,吗啡/6-单乙吗啡,EDDP/甲) 显示出潜在的外部血液污染指标.

结论:

血液对头发的外部污染导致阿片类药物和阿片类药物的快速结合.
这项研究强调了法医头发药物测试中由于血液污染导致假阳性结果的风险.
代谢物与原始药物比率可以作为有价值的生物标志物,以区分系统内置和外部污染.

关键词:

外部污染其他污染法医医学法医学的研究.检测头发检测头发检测头发片类药物/阿片类药物

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