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巨生物减轻微囊气球菌诱导的鱼类食欲抑制通过肠道代谢物调节

Minmin Niu¹, Keira Harshaw², Qianqian Xiang¹

¹Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China.

Ecotoxicology and environmental safety

|November 17, 2024

概括

菌的繁殖会通过改变调节食欲的激素,对鱼类的食欲产生负面影响. 水生植物可以通过影响肠道代谢物和神经内分泌因子来减轻这些影响.

科学领域:

环境毒理学环境毒理学
水生生态学水生生态学
鱼类生理学鱼类生理学

背景情况:

蓝藻细菌的繁殖和水生巨型生物可以对淡水鱼的健康和行为产生负面影响.
鱼的食欲和肠道代谢物的变化是环境压力的关键指标.

研究的目的:

研究Microcystis aeruginosa和Ottelia acuminata对石头摩洛哥 (Pseudorasbora parva) 健康,食欲调节和肠道新陈代谢的影响.
了解水生植物如何缓解蓝菌对鱼类的影响.

主要方法:

石头摩洛哥被暴露在M. aeruginosa和/或O. acuminata中96小时.
分析了鱼类健康指标,食欲调节激素 (CART,GLP-1,素) 和肠道代谢组.
代谢分析的重点是脂质,氨基酸和胆固醇代谢.

主要成果:

单独O. acuminata对测试的指标没有影响.
暴露于M. aeruginosa会增加食欲抑制因子 (CART,GLP-1) 和减少刺激因子 (orexin).
暴露于M. aeruginosa与改变的脂质,氨基酸和胆固醇代谢物相关,特别是胆酸合成.
O. acuminata的存在减少了M. aeruginosa对神经内分泌因子的不良影响,可能是通过改变肠道氨基酸代谢.

结论:

菌明显扰乱了鱼的食欲调节和肠道新陈代谢.
O. acuminata可能会对蓝色细菌毒素产生保护作用,可能是通过调节肠道代谢产物.
需要进一步的研究来阐明O. acuminata缓和作用的确切机制.

关键词:

蓝藻细菌的花朵在放.鱼类食欲调节法规鱼类食欲调节法规它的肠道代谢产物.微囊气球菌的微囊.这种植物是Ottelia acuminata.这是一个假的Pseudorasbora parva.

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