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Updated: Jun 7, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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六价诱导了通过PDK1上调调节的代谢重编程,致癌和瘤进展

Wen-Jing Liu1, Lin Wang2, Fan-Li Sun3

  • 1The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.

Ecotoxicology and environmental safety
|November 17, 2024
PubMed
概括

六价 (Cr(VI)) 暴露会通过抑制miR-493诱导肺癌,导致PDK1和HIF-1α的增加. 这种miR-493/HIF-1α/PDK1通路驱动瘤生长,并与不良的肺癌预后有关.

关键词:
致癌,肺癌的发展,肺癌的发生.这就是HIF-1α.六价的六价是一种在 MiR-493 的位置上.在PDK1中,PDK1是

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