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Xin-Chen Tan¹, Xin-Yun Song², Meng-Qi Jiang²

¹Department of Radiation Oncology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, PR China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, PR China.

Translational oncology

|November 17, 2024

概括

对非小细胞肺癌 (NSCLC) 的新辅助疗法进行比较时,化疗免疫疗法显示出强烈的病理反应和长期存活率,而向疗法对成像效益有所改善,但结果不那么持久.

科学领域:

在瘤学瘤学.
胸部外科手术胸部外科手术
临床试验临床试验

背景情况:

新辅助疗法是可手术的非小细胞肺癌 (NSCLC) 的标准.
仅有有限的数据可以比较化学免疫疗法,向疗法和同一机构内的化学疗法.
了解差异化治疗效益对于优化患者的治疗结果至关重要.

研究的目的:

为了比较不同新辅助疗法在NSCLC的短期放射和病理疗效.
评估这些疗法对长期无事件生存 (EFS) 的影响.
评估观察到的治疗差异的临床意义.

主要方法:

对243名接受新辅助化学免疫疗法,向疗法或化疗的NSCLC患者的回顾性分析.
评估客观反应率 (ORR),主要病理反应 (MPR) 和病理完整反应 (pCR).
卡普兰-梅尔分析无事件生存 (EFS) 和科恩的卡帕图像-病理相关性.

主要成果:

化疗免疫疗法显示出高的MPR (58.74%) 和pCR (41.26%) 率.
向治疗显示了最高的ORR (57.58%),但0%的PCR.
化学免疫疗法和化疗组的MPR与更长的EFS相关,但不是向治疗.

结论:

新辅助化学免疫疗法可能会低估成像上的病理反应,但会产生一致的长期结果.
新辅助化疗显示了短期益处与减少复发之间的联系.
新辅助向治疗提供初始成像效益,但持续生存改善有限.

关键词:

主要病理反应的主要病理反应新辅助疗法是一种新辅助疗法.非小细胞肺癌是非小细胞肺癌.辐射疗效辐射疗效辐射疗效复发复发的情况

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