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Updated: Jun 7, 2025

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克拉斯在调节IDO1表达方面起着负面作用

Xiandong Peng1, Eunji Lee1, Jialu Liang1

  • 1Division of Environmental Medicine, Department of Medicine, Grossman School of Medicine, New York University, 341 East 25th Street, New York, NY 10010, USA.

Translational oncology
|November 17, 2024
PubMed
概括

拉斯信号消极地调节了Indoleamine 2,3-dioxygenase-1 (IDO1) 的表达,同时促进了KRas突变癌症中编程细胞死亡蛋白1联体1 (PD-L1) 的表达. 抑制KRasG12C会增加IDO1,这表明KRas和IDO1联合向癌症治疗.

关键词:
标签: 标签: IDO1 标签: IDO1 标签: IDO1免疫检查站检查站干扰素-r 是一种干扰素.克拉斯克拉斯克拉斯克拉斯Kras在PD-L1中.

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