格内图丁A通过激活PI3K/AKT/mTOR依赖的自途径来防止缺血性中风
Danyang Mu1, Jingyu Liu1, Yan Mi1
1Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, Northeastern University, Shenyang, China.
格内图宾丁A (GA) 通过通过PI3K/AKT/mTOR通路增强自性,从而防止缺血性中风 (IS). 这项研究揭示了GA作为IS的潜在治疗剂,通过调节自.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 自是缺血性中风 (IS) 发病的一个关键因素,也是潜在的治疗标.
- 一种用于炎症疾病的植物Gnetum parvifolium含有未明确作用的化合物.
- 来自Gnetum parvifolium的stilbeneGnetupindin A (GA) 具有未知的药理作用.
研究的目的:
- 确定Gnetupindin A (GA) 对缺血性中风 (IS) 的治疗潜力.
- 探索GA调节IS中自的机制.
- 研究GA的神经保护作用及其分子点.
主要方法:
- 使用中脑动脉封闭-再输血 (MCAO/R) 和缺氧-葡萄糖再输血 (OGD/R) 细胞的小鼠模型.
- 使用腺相关病毒 (AAV) 进行Atg5敲击和3-甲基氨酸 (3-MA) 作为自抑制剂.
- 应用了分子对接,CETSA和DARTS来识别GA的目标,用于验证PI3K抑制剂LY294002.
主要成果:
- 在IS模型中,GA治疗显著降低了脑梗塞的体积,,神经缺陷和亡.
- 在体内和体外,GA促进了自流,Atg5的敲击取消了它的神经保护作用.
- GA专门针对PI3K,抑制PI3K/AKT/mTOR通路,而LY294002则逆转了GA的影响.
结论:
- 格内图宾丁A (GA) 显示出对缺血性中风 (IS) 的神经保护作用.
- 通过PI3K/AKT/mTOR信号通路促进自,GA发挥其保护作用.
- 这项研究为GA的抗IS机制提供了新的见解,其中包括自调节.
更多相关视频
08:00Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
Published on: July 10, 2019
07:40Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
The JAK-STAT Signaling Pathway
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Autophagy
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
