一种不良结果途径方法,将视网体信号干扰与致性和人口水平结果联系起来
Audrey Phan1, Aleksandra Sokolova1, Klara Hilscherova1
1RECETOX, Faculty of Science, Masaryk University, 62500, Brno, Czech Republic.
Aquatic toxicology (Amsterdam, Netherlands)
|November 17, 2024
概括
视网体信号干扰会导致斑马鱼的致死性和降低生存率. 本研究定义了一个不良结果路径网络,将视网膜酸受体过度激活与发育缺陷和人口层面的影响联系起来.
科学领域:
- 环境毒理学环境毒理学
- 发展生物学 发展生物学
- 内分泌干扰 干扰内分泌系统
背景情况:
- 内分泌干扰研究正在扩展到超越雌激素,雄激素,甲状腺和类固醇生成途径.
- 视网体信号干扰是一个严重的问题,因为它具有原性潜力和环境相关性.
- 目前的环境风险评估很难有效地评估个人和人口层面的影响.
研究的目的:
- 描述一个不良结果途径 (AOP) 网络,将视网体信号干扰与斑马鱼的致性和生存联系起来.
- 为了确定特定发育效应的关键敏感度窗口.
- 量化发展影响并评估对更高生物水平的影响.
主要方法:
- 使用斑马鱼作为模型生物.
- 研究了视网膜酸受体 (RAR) 过度激活的分子发起事件.
- 量化面形 (CFM) 和尾部形 (TM),后游膀 (SB) 非膨胀,食,游泳,以及在全转网红酸 (ATRA) 暴露后的生存率.
主要成果:
- 确定RAR过度激活是视网质破坏的分子启动事件.
- 对于CFM,TM和后部SB非膨胀的确定灵敏度窗口 (4-48 hpf).
- 尾部形 (TM) 显示出高灵敏度 (EC50:0.2-0.26μg/L),而ATRA暴露 (1μg/L) 导致显著的食抑制和降低生存率.
结论:
- 建立了与监管相关的框架,将视网体信号干扰与斑马鱼的不良结果联系起来.
- 突出了与视网干扰剂相关的生态风险.
- 强调需要改进对内分泌干扰化学品的环境风险评估策略.
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