在接受头癌治疗的患者中挥发性硫化合物和唾液参数:一项初步研究
Juliana Maria Braga Sclauser1, Karolina Skarlet Silva Viana1, José Alcides Almeida de Arruda2
1Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, room 3105, Belo Horizonte, MG CEP: 31270-901, Brazil.
Journal of stomatology, oral and maxillofacial surgery
|November 17, 2024
概括
头癌治疗影响唾液,减少流量和pH值,同时增加粘度. 患者的治疗后口臭与较高的硫化水平相关,尽管挥发性硫化合物 (VSC) 的总体变化没有.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 生物化学 生化学
背景情况:
- 头部和部状细胞癌 (HNSCC) 治疗可能会导致诸如唾液参数变化和口臭等不良影响.
- 了解这些变化对于在癌症治疗期间管理患者的生活质量至关重要.
研究的目的:
- 调查正在接受治疗的HNSCC患者挥发性硫化合物 (VSC) 水平和唾液参数的变化.
- 为了将这些变化与报告的口臭和治疗方式相关联.
主要方法:
- 对24名接受放射治疗或化学放射治疗的HNSCC患者进行前性纵向研究.
- 在治疗前和治疗后评估VSC水平,唾液流量,pH值,粘度,口腔干燥和舌头涂层.
- 使用口腔ChromaTM气色谱仪测量VSC;数据被描述性和分析性地分析.
主要成果:
- 治疗后观察到唾液流量 (p < 0.001) 和pH (p = 0.017) 的显著减少.
- 发现唾液粘度显著增加 (p = 0.037).
- 报告有口臭的患者的硫化水平显着更高 (p = 0.045);整体VSC水平和舌头涂层没有显著变化.
结论:
- 治疗HNSCC导致唾液流量减少,pH值改变,粘度增加.
- 自我报告的口臭治疗后与硫化的升高有关,尽管总体VSC度保持不变.
- 这些发现凸显了HNSCC治疗对口腔健康的影响.
更多相关视频
相关概念视频
Sputum Studies II: Culture and Sensitivity
259
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
259
Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture
166
Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
166
Salivary Glands and Saliva
486
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
486
Sulfur Assimilation
1
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
1
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Acute Respiratory Failure-V
123
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
123


