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Updated: Jun 7, 2025

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提高疼痛研究的可信度:呼吁采取行动

, Neil E O'Connell¹, Joletta Belton²

¹Department of Health Sciences, Centre for Wellbeing Across the Lifecourse, Brunel University London, United Kingdom.

The journal of pain

|November 17, 2024

概括

慢性疼痛研究面临重大挑战,包括治理和透明度不足,影响患者护理. 一个新的框架,ENTRUST-PE,旨在提高疼痛科学的可信度,以获得更好的解决方案.

科学领域:

疼痛研究疼痛研究
卫生研究卫生研究
基于证据的实践实践.

背景情况:

慢性疼痛给个人,社会和经济带来了巨大的负担.
目前的研究实践表现出结构性弱点,包括治理不足,多样性,利益相关方参与,方法论严谨,透明度和平衡的沟通.
这些问题影响着所有研究阶段,从临床前研究到临床试验和系统审查,影响临床指导和实践.

研究的目的:

识别和探索危及疼痛科学可信度的关键挑战.
引入一个新的,综合的概念框架,ENTRUST-PE,旨在提高疼痛研究的可信度.
倡导利益相关者之间采取集体行动,以提高疼痛研究的可靠性和影响.

主要方法:

分析慢性疼痛研究当前证据架构中的结构性弱点.
检查当代示例,说明疼痛科学中的挑战.
开发和介绍ENTRUST-PE框架,为利益相关者提供建议.

主要成果:

确定了疼痛研究中的多个结构性弱点,包括不完整的治理,缺乏多样性,缺乏严格性和数据透明度问题.
突出了研究不当行为和不真实的数据带来的风险,导致不确定性和低价值护理.
提出了ENTRUST-PE框架作为一种新的解决方案,以加强疼痛研究的可信度.

结论:

解决疼痛研究中的系统性问题对于改善患者的治疗结果和促进科学理解至关重要.
恩思特-PE框架提供了一种结构化的方法,以提高研究的完整性和可信度.
对于疼痛研究界来说,需要一个集体的行动呼吁,以实现这些改进,并促进对疼痛科学的更大的信任.

关键词:

参与参与参与参与股权资本股权资本诚信诚信是一种诚信.严谨性严谨性严谨性透明度透明度透明度可信度值得信赖值得信赖

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