人类中性粒细胞与Trichomonas vaginalis原生动物的相互作用突出显示了乳酸的分泌
Wei-Hung Cheng1, Ruei-Min Chen2, Seow-Chin Ong2
1Department of Parasitology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
概括
阴道虫 (Trichomonas vaginalis) 通过诱导乳酸铁素分泌来吸引中性粒细胞. 这种寄生虫衍生的乳酸,一种铁来源,增强了T. vaginalis感染期间的生存,揭示了新的宿主-病原体相互作用机制.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 微生物学 微生物学
背景情况:
- 中性粒细胞对于阴道免疫力对抗三病至关重要.
- 阴道菌 (Trichomonas vaginalis,T. vaginalis) 会分泌白血素B4 (LTB4) 并诱导白血素-8 (IL-8) 来招募中性粒细胞.
- 寄生虫促进中性粒细胞相互作用的策略尚未完全理解.
研究的目的:
- 为了研究T. vaginalis和人类中性粒细胞之间的分子相互作用.
- 为了确定在阴道感染期间参与宿主寄生虫相互作用的特定蛋白质.
主要方法:
- 与人类中性粒细胞共同培养T. vaginalis.
- 使用质谱学对可溶性分泌/分泌蛋白 (ESP) 的蛋白质组分析.
- 评估乳酸分泌及其对T. vaginalis存活率的影响.
主要成果:
- 综合分析确定了192个ESP,其中94个具有特征.
- 乳二仅在中性粒细胞与T. vaginalis相互作用时分泌,这是一个依赖接触的过程.
- 含铁的乳酸在缺乏铁的条件下显著延长了T. vaginalis的存活时间.
结论:
- 这项研究首先确定了乳酸铁作为一种主要分子,其起源于T. vaginalis感染中的宿主-寄生虫相互作用.
- 阴道菌吸引中性粒细胞获取乳酸铁素,这是一个重要的铁源.
- 这一发现阐明了通过利用宿主免疫成分来实现寄生虫生存和持续的机制.
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