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双相情感障碍患者的甲状腺激素水平:系统性审查和元分析
Shanshan Liu1,2,3, Xiaoai Chen2,4,3, Xiaotao Li2,5,3
1The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
BMC endocrine disorders
|November 17, 2024
概括
甲状腺激素水平在双相情感障碍 (BD) 中不同. 与对照组相比,T3和自由T3在抑郁发作中较低,而T3在躁狂发作中较低,自由甲状腺素 (FT4) 在躁狂发作中较高.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 双极性障碍 (BD) 是一种复杂的情绪障碍.
- 甲状腺激素 (TH) 在情绪调节中起着至关重要的作用.
- 在BD病理生理学中,TH水平的变化与BD病理生理学有关.
研究的目的:
- 系统地调查和比较双相情感障碍 (BD) 患者在抑郁和躁狂发作期间的血液甲状腺激素 (TH) 水平.
- 为了比较BD患者和健康对照 (HC) 之间的TH水平.
- 为了检查BD内的躁狂和抑郁情节之间的TH水平的差异.
主要方法:
- 在多个电子数据库中进行了全面的系统文献搜索,截至2024年9月1日.
- 包括涉及血清/血甲状腺刺激激素 (TSH),甲状腺素 (T4),三甲状腺素 (T3),自由甲状腺素 (FT4) 和自由三甲状腺素 (FT3) 在BD和HC中的研究.
- 随机效应模型被用于计算标准化平均差异 (SMD) 以95%的置信区间 (CI) 来评估异质性.
主要成果:
- 与HC相比,在BD抑郁症发作中,血清T3和FT3水平显著下降.
- 与HC相比,在BD躁狂发作中,血清T3水平显著下降,FT4水平显著增加.
- 与BD抑郁期相比,BD躁狂期的血清T3和FT3水平显著升高.
结论:
- 在不同情绪状态期间,在双相情绪障碍中观察到血清T3,FT3和FT4水平的显著变化.
- 这些发现表明甲状腺激素失调在双相情感障碍的病理生理学中的潜在作用.
- 需要进一步的纵向研究来阐明TH水平变化和BD进展之间的时间关系.
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