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Updated: Jun 7, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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Assays for the Degradation of Misfolded Proteins in Cells

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由于TSG101的枯竭导致线粒体和PML NBs的失调,通过AIFM1-PML-DAXX通路引发MAD2-过度表达的细胞间相死亡 (MOID)

Yao Xi1,2, Rui Xu1,2, Shengnan Chen1,2

  • 1National Resource Center for Mutant Mice, MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Medical School of Nanjing University, Nanjing, 210061, China.

Cell death & disease
|November 17, 2024
PubMed
概括

过度表达的线粒体停止缺陷2 (MAD2) 与瘤敏感性基因101 (TSG101) 的枯竭相结合,触发了一种称为MOID的新型细胞死亡途径. 这个过程涉及线粒体功能障碍和PML核体,影响癌细胞生存.

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