在精神分裂症患者中,Lactobacillus和Bifidobacterium的疗效:一个元分析
Mi Yang1,2,3, Xingxing Cui4, Di Kong4
1Department of Psychiatry, The Fourth People's Hospital of Chengdu, No. 8 Huli-West 1st-Alley, Jin-Niu District, Chengdu, 610036, China. 565136170@qq.com.
European archives of psychiatry and clinical neuroscience
|November 17, 2024
概括
益生菌可以通过改善症状和减少胃肠道问题来帮助治疗精神分裂症. 这一系统性审查发现,接受益生菌治疗的精神分裂症患者的整体症状得分和代谢标记有显著的益处.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症是一种复杂的精神障碍,治疗选择有限.
- 通过益生菌对肠道微生物群进行调节,呈现出一种新的治疗策略.
- 现有的研究表明,在精神分裂症中,肠-大脑轴连接.
研究的目的:
- 系统地分析益生菌补充治疗在精神分裂症患者的疗效.
- 研究益生菌作用的潜在机制和临床影响.
- 综合来自对治疗精神分裂症的益生菌的随机对照试验 (RCT) 的证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在多个数据库 (Medline,Embase等) 进行了搜索. 在2023年7月1日之前发布的RCT.
- 包括8个RCT,其中342名参与者在益生菌组和306名参与者在对照组.
主要成果:
- 益生菌治疗显著降低了整体阳性和阴性综合征量表 (PANSS) 评分 (p=0.03).
- 在胰岛素水平,胰岛素抵抗指数 (IRI) 和葡萄糖水平 (p<0.05) 中观察到显著改善.
- 益生菌显著减少了精神分裂症患者的胃肠道不适 (p=0.003).
结论:
- 益生菌显示出对精神分裂症的治疗潜力,解决临床症状,代谢异常和肠道健康问题.
- 益生菌疗法可以改善葡萄糖代谢,并减少精神分裂症中胃肠道的痛苦.
- 基于证据的方法需要通过比较试验和多种益生菌菌株进行进一步的研究.
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