微生物托芬代谢中断与SARS-CoV-2急性炎症反应和长期COVID相关
Lu Yao1,2, Hannah Devotta1,2, Junhui Li1,2
1School of Microbiology, University College Cork, Cork, Ireland.
Gut microbes
|November 17, 2024
概括
肠道微生物影响COVID-19的严重程度. 肠道细菌的低托代谢与严重的COVID-19和长期的COVID有关,可能是由于免疫反应受损. 识别微生物组对托代谢的能力可以识别有风险的个体.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 肠道微生物组的改变与SARS-CoV-2感染严重程度和长期COVID有关.
- 导致这些影响的特定微生物机制尚不清楚.
- 肠道微生物对托芬的代谢可能会影响对病毒感染的免疫反应.
研究的目的:
- 研究微生物托代谢在COVID-19和长期COVID中的作用.
- 在患者中探索托代谢产物与免疫媒介水平之间的关联.
- 为了确定微生物托代谢能力的降低是否与严重的COVID-19结果相关.
主要方法:
- 在COVID-19和长期COVID患者中对托芬及其代谢物的血清分析.
- 代谢物水平和炎症标志物之间的相关性分析.
- 便元基因组测序以评估微生物基因对托代谢的作用.
- 在体外和体外测试以评估微生物托代谢物对免疫细胞反应的影响.
主要成果:
- 和英多尔-3- (IPA) 与促炎介质有负相关性,而其他代谢物 (C-Trp,ILA,IAA) 则具有正相关性.
- 与对照组相比,在住院COVID-19患者中观察到微生物托芬生产和代谢基因的丰度减少.
- 微生物托代谢物在体外和体外调节了先天和适应性免疫反应,减少了促炎性细胞因子,增强了IL-22.
结论:
- 低微生物托芬生产和新陈代谢可能会增加SARS-CoV-2感染后严重和慢性结果的风险.
- 由于托代谢发生变化,导致先天性和适应性免疫反应受损可能会导致COVID-19的严重程度.
- 评估微生物组对托芬代谢的能力可能有助于识别患重症COVID-19和长期COVID的风险较高的人.
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