在结直肠癌中使用ctDNA引导的辅助免疫疗法
Nicholas Burley1,2, Yurhee Lee1,2, Louisa Liu1
1Division of Medical Oncology, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Immunotherapy
|November 18, 2024
概括
结直肠癌 (CRC) 中的最小残留疾病 (MRD) 可以通过循环瘤DNA (ctDNA) 监测. 在dMMR/MSI-HIII期CRC中,化疗可能无法清除ctDNA,但pembrolizumab确实可以,这表明免疫疗法.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 癌症基因组学 癌症基因组学
背景情况:
- 循环瘤DNA (ctDNA) 是结直肠癌 (CRC) 中最小残留疾病 (MRD) 的关键生物标志物.
- 免疫疗法是转移性不匹配修复缺陷/微卫星不稳定性高 (dMMR/MSI-H) CRC 的标准,但其在早期阶段的作用正在出现.
- 在切除的dMMR/MSI-HII期CRC中不建议使用辅助性胺,而新辅助疗法在局部dMMR/MSI-HCRC中显示益处降低.
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