通过酶性血红素消化设计纳米血红素用于铁死介导的细胞死亡
Abu Raihan Sarkar1, Nayana Mukherjee1, Ankan Kumar Sarkar1
1School of Materials Science, Indian Association for the Cultivation of Science, Kolkata 700 032, India.
ACS applied materials & interfaces
|November 18, 2024
概括
纳米-黑纳米粒子增强反应性氧物种 (ROS) 生成,用于向癌症治疗. 这种新型配方诱导铁或自,为各种治疗应用提供模块化细胞毒性.
科学领域:
- 生物化学 生物化学
- 纳米技术 纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 黑是一种铁离子原氨酸复合体,产生反应性氧物种 (ROS),但其生物可用性较低.
- 半膜产生的ROS可以诱导氧化应激,导致细胞中的铁亡或自.
- 黑的治疗功效目前的局限性源于其生物可用性差和不稳定的ROS生成.
研究的目的:
- 开发一种纳米血红素配方,增强ROS生成和细胞吸收.
- 研究纳米血红素诱导细胞死亡的机制,特别是铁和自.
- 探索调节纳米血红素细胞毒性的潜力,用于治疗应用.
主要方法:
- 体纳米黑颗粒的合成和表征.
- 评估ROS生成和纳米-hemin的细胞吸收.
- 对纳米血红素对血红氧酶-1表达和细胞死亡途径 (ferroptosis,自) 的影响的评估.
主要成果:
- 与原生血红素相比,纳米血红素表现出明显更高的ROS生成和细胞吸收.
- 纳米血红素的细胞内ROS产生调节血红素酶-1,促进铁灭症介导的细胞死亡.
- 纳米血红素的ROS生成可以调节,以选择性地诱导铁或自.
结论:
- 纳米黑是一种有前途的治疗剂,具有改善的生物可用性和ROS产生能力.
- 纳米血红素通过ROS生产和血红素氧酶-1上调有效诱导铁.
- 纳米hemin的可调节的细胞毒性允许定制的治疗策略,针对各种疾病的ferroptosis或自.
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