维生素D补充剂对抑郁症的影响:随机对照试验的系统审查和剂量反应元分析
Shadi Ghaemi1, Sheida Zeraattalab-Motlagh1,2, Ahmad Jayedi1,3
1Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Psychological medicine
|November 18, 2024
概括
维生素D3补充剂显示了抑郁症状的轻微减少,特别是在现有抑郁症的个体中. 然而,它并没有显著影响焦虑症状.
科学领域:
- 营养精神病学 营养精神病学
- 临床心理学 临床心理学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D在心理健康,特别是抑郁和焦虑方面的作用是正在进行的研究领域.
- 之前对维生素D补充剂及其对情绪障碍的影响的研究已经产生了不一致的结果,需要进一步调查剂量依赖的影响.
研究的目的:
- 研究维生素D3补充剂对成人抑郁和焦虑症状的剂量依赖性影响.
- 系统地审查和分析现有的随机对照试验 (RCT),以确定维生素D3补充剂对情绪障碍的疗效.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了系统的文献搜索,截至2022年12月.
- 包括的RCT评估了成人对抑郁和焦虑症状的维生素D3补充.
- 使用随机效应模型计算标准化平均差异 (SMD) 每1000IU/天,用GRADE工具评估证据确定性.
主要成果:
- 对31项涉及24,189名参与者的试验的分析表明,每1000 IU/天的维生素D3在健康个体和抑郁症患者 (GRADE:中度) 中都略有减少了抑郁症状 (SMD: -0.32).
- 抗抑郁药的效果在患有抑郁症状的个体中更为明显 (SMD: -0.57),在每天8000 IU (SMD: -2.04) 观察到的最大减少.
- 较短的试验持续时间 (≤24周) 与较长的持续时间 (>52周) 相比显示出更强的效果,而维生素D3补充剂对焦虑症状没有显著影响.
结论:
- 维生素D3补充似乎在短期内有效地减少抑郁症状,具有显著的剂量依赖关系.
- 目前的证据表明,对焦虑症状没有显著的益处. 建议进一步进行高质量的研究,以全面理解,特别是关于焦虑的问题.
- 这些发现支持维生素D3作为抑郁症辅助疗法的潜在作用,特别是在更高剂量和更短的治疗时间下.
相关概念视频
Depression: Overview
219
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
219
Antidepressant Drugs: MAOIs and Other Agents
195
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
195
Depressive Disorders: Etiology
51
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
51
Depressive Disorders: MDD and Dysthymia
61
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
61
Role of Skin in Vitamin D Synthesis
5.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.0K
Antidepressant Drugs: Overview
365
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
365


