在先前未服用药物的第一发精神分裂症中的功能梯度功能障碍及其与特定的转录模式及其治疗预测的相关性
Guanqun Yao1,2, Jing Luo2,3, Jing Li1,4,5
1Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.
Psychological medicine
|November 18, 2024
概括
第一发精神分裂症 (FES) 显示与基因表达相关的脑连接梯度变化,并预测治疗反应. 这些发现揭示了FES中大脑功能和遗传模式之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 第一发精神分裂症 (FES) 是一种进展性疾病,具有未知的功能梯度缺陷.
- 这些缺陷,基因表达和FES治疗结果之间的关系尚不清楚.
研究的目的:
- 为了研究在未使用过毒品的FES中功能梯度缺陷.
- 探索这些缺陷,基因表达和治疗结果之间的联系.
主要方法:
- 在116名FES患者和100名健康对照 (HC) 中分析了基于voxel的连接梯度.
- 利用网络拓,基因表达和机器学习进行功能和转录分析.
- 在8周的抗精神病治疗期间检查了15名FES患者.
主要成果:
- FES表现出减少的全球连接体梯度,特别是在默认和传感运动网络中,与集成/分离功能相关联.
- 鉴定了基因表达特征与其他精神疾病的重叠;丰富的基因涉及突触信号和神经发育.
- 开始年龄影响了FES的严重程度,基线连接梯度预测了治疗结果.
结论:
- 在FES中,宏观的功能连接度梯度和微观的转录模式是紧密联系在一起的.
- 结果提供了关于FES发病和进展的理论见解.
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