在患有克罗恩氏病的患者中,皮下Infliximab度值可用于粘膜和外壁治疗
Sung Noh Hong1, Joo Hye Song1, Sung Jin Kim1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
皮下注射infliximab (SC-IFX) 前剂量最低度 (Ctrough) 与克罗恩病 (CD) 的治疗成功有关. 更高的SC-IFX C通道水平与改善的粘膜和外壁治疗相关.
科学领域:
- 胃肠病学 胃肠病学
- 药理动力学 药理动力学
- 免疫学 免疫学 免疫学
背景情况:
- 静脉注射因弗利西马布 (IV-IFX) 的最低度是克罗恩病 (CD) 治疗结果的关键.
- 皮下注射的infliximab (SC-IFX) 具有良好的药理动力学,导致Ctrough值更高.
研究的目的:
- 评估SC-IFX Ctrough与CD患者治疗结果之间的关系.
- 确定SC-IFX Ctrough的值,以实现粘膜愈合 (MH) 和跨壁愈合 (TH).
主要方法:
- 对SC-IFX维持疗法 (≥6个月) 的CD患者进行横截面研究.
- 在注射前测量SC-IFX Ctrough;通过内镜和MRI在3个月内评估MH和TH.
- 定义MH为0的SES-CD分数,TH为0.0的简化玛丽亚分数.
主要成果:
- 在获得MH (24.1比16.9微克/毫升) 和TH (26.0比20.5微克/毫升) 的患者中,SC-IFX Ctrough显著更高.
- 在ROC分析中,MH的Ctrough值为17.5微克/毫升,TH的Ctrough值为30.3微克/毫升.
- 多变量分析证实SC-IFX C通与MH (OR 1.16) 和TH (OR 1.08) 有关.
结论:
- 在CD患者中,SC-IFX Ctrough与MH (≥18微克/毫升) 和TH (≥30微克/毫升) 有积极的关联.
- 这些发现支持一种治疗到目标的策略,以优化SC-IFX疗法在CD.
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