卵巢刺激对林分泌和生殖潜力的影响
Fernando Beltramone1, Patricia Estofán1, Noelia Piccinali1
1Centro Integral de Ginecología, Obstetricia y Reproducción de Córdoba, Córdoba, Argentina.
Clinical endocrinology
|November 18, 2024
概括
在辅助生殖中,卵巢刺激会增加林 (Ghrl) 和性激素水平,影响母亲的免疫细胞和怀孕结果. 需要进一步的研究来澄清格林在流产中的作用.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 免疫学 免疫学 免疫学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 在怀孕早期, ghrelin (Ghrl) 分泌需要精确的调节.
- 林水平升高可能会对生育能力产生负面影响.
- 雌激素刺激胆固醇合成,在卵巢刺激 (OS) 期间可能增加胆固醇血症.
研究的目的:
- 为了调查卵巢刺激 (OS) 是否会在接受辅助生殖的妇女中增加 ghrelinemia.
- 评估OS诱导的 ghrelinemia,母体内分泌和免疫生物标志物和生殖成功之间的关联.
主要方法:
- 一组97名接受辅助生殖的妇女被分为三个组:OS (新鲜胚胎移植),FET (冷胚胎移植) 和OD (卵子捐赠).
- 在胚胎移植当天测量了雌激素,孕和 ghrelin (Ghrl) 的血清水平.
- 评估了内分泌和免疫生物标志物,包括T细胞和子宫自然杀手 (uNK) /NK细胞比率.
主要成果:
- 与非刺激组相比,接受OS的女性的血清雌激素,孕和Ghrl显著增加.
- 经历流产的患者的性激素度较低,Ghrl.也有类似的趋势.
- OS与循环T细胞频率降低和uNK/NK细胞比率降低有关,与性激素水平相关.
结论:
- 卵巢刺激显著增加了血清格林 (Ghrl) 和性激素水平,与免疫反应和生殖结果相关.
- 虽然格林与性激素的趋势相似,但其与流产有关的统计学意义需要进一步调查.
- 特定的T细胞和uNK/NK细胞的母体免疫切断值被确定为临床怀孕和流产的预测值.
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