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相关概念视频

The Micturition Reflex01:26

The Micturition Reflex

453
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
453

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相关实验视频

Updated: Jun 7, 2025

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
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鼠标膀光滑肌肉缺乏功能性活性NMDAR

Zhean Zhan1,2, Zhibin Chen3, Xiaoli Zheng1

  • 1The School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan, China.

Neurourology and urodynamics
|November 18, 2024
PubMed
概括

这项研究没有发现膀光滑肌 (BSM) 中功能性N-甲基-D-酸盐受体 (NMDARs) 的证据. 因此,NMDAR不太可能是作用于BSM的过度活性膀治疗的直接目标.

关键词:
在MK-801中,我们可以看到MK-801.N-甲基-D-阿斯巴达酸盐受体的受体膀 膀 膀 膀 是一个膀平滑肌肉 膀平滑肌肉 是一个过度活跃的人过度活跃.

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科学领域:

  • 生理学 生理学 生理学
  • 药理学 药理学是指药理学的学科.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科

背景情况:

  • 过度活性膀 (OAB) 是一种影响膀光滑肌 (BSM) 功能的疾病.
  • N-甲基-D-酸盐受体 (NMDARs) 涉及各种生理过程,但它们在BSM中的作用尚不清楚.
  • 在BSM中研究NMDAR可能会揭示OAB的新疗法目标.

研究的目的:

  • 在膀光滑肌 (BSM) 中确定NMDARs的存在和功能.
  • 评估NMDARs作为过活性膀 (OAB) 的治疗点的潜力.

主要方法:

  • 肌谱被用来测量BSM对NMDAR调节器的收缩反应.
  • 成像评估了BSM细胞中的细胞内离子变化.
  • 单细胞RNA测序和免疫光定位NMDAR亚单元表达在人类和小鼠BSM.

主要成果:

  • NMDAR激动剂没有影响BSM收缩.
  • NMDAR对手表现出多种效果,其中MK-801增强了收缩.
  • 通过RNA测序或免疫光检测,在BSM细胞中没有检测到NMDAR亚单元的表达,尽管在肺动脉光滑肌中发现了GluN1.

结论:

  • 在膀光滑肌 (BSM) 中没有功能性NMDAR.
  • 在过度活性膀 (OAB) 中NMDAR抑制的治疗效果不太可能由BSM直接调解.
  • 需要进一步的研究来确定OAB治疗的替代机制和目标.