优化患有人类免疫缺陷病毒的人的心脏代谢风险:深入研究一个重要的风险增强剂
Elizabeth A Kobe1, Aarti Thakkar1, Sarina Matai2
1Duke University Hospitals, 2301 Erwin Road, Suite 7400, Cubicle 13, Durham, NC 27710, USA.
American journal of preventive cardiology
|November 18, 2024
概括
抗逆转录病毒疗法 (ART) 改善了人类免疫缺陷病毒 (HIV) 患者的生存率,但增加了他们患动脉样硬化心血管疾病 (ASCVD) 的风险. 本综述涵盖了艾滋病病毒.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 有效的抗逆转录病毒疗法 (ART) 导致人类免疫缺陷病毒 (HIV) 感染者人口老龄化.
- 艾滋病毒是动脉样硬化心血管疾病 (ASCVD) 的独立风险因素,正如主要心脏病指南所承认的那样.
- 随着艾滋病毒人口的老龄化,慢性疾病的风险增加,特别是ASCVD,需要集中心血管风险管理.
研究的目的:
- 审查将艾滋病毒与动脉生成联系起来的流行病学和发病学.
- 讨论艾滋病毒感染者的特定心脏代谢风险因子修改 (PLWH).
主要方法:
- 文献综述,重点关注艾滋病毒,动脉动脉生成和心血管风险因素.
- 综合当前关于艾滋病毒对心血管健康影响的证据.
- 在PLWH中分析心脏代谢风险的管理策略.
主要成果:
- 艾滋病毒通过各种机制加速动脉动脉生成,增加ASCVD风险.
- 在PLWH中的关键心脏代谢风险因素包括肥胖,高血压,胰岛素耐药性,代谢功能障碍相关的脂肪性肝病和脂质失调症.
- 管理策略必须根据PLWH的独特形象进行调整.
结论:
- 了解艾滋病毒和ASCVD之间的联系对于临床实践至关重要.
- 针对心脏代谢风险因素的向修改可以减轻PLWH中ASCVD事件.
- 需要进一步的研究,以优化对老龄化艾滋病毒人口的心血管护理.
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